Use & Important Safety Information
Do not take ONAPGO if you are:
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taking certain medicines to treat nausea (ondansetron, granisetron, dolasetron, palonosetron) and alosetron. People
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taking certain medicines to treat nausea (ondansetron, granisetron, dolasetron, palonosetron) and alosetron. People taking ondansetron with apomorphine had very low blood pressure
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ONAPGO is a prescription medicine used to treat motor fluctuations (OFF episodes) in adults with advanced Parkinson’s disease (PD). It is not known if ONAPGO is safe and effective in children.
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blood clots. Infusing ONAPGO into a vein (intravenous)
can cause blood clots. Do not infuse ONAPGO in your
vein.
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nausea and vomiting are common. May be serious or severe. Your healthcare provider may prescribe medicine (trimethobenzamide) to help
decrease nausea/vomiting. OR adjust your ONAPGO dosing to manage symptoms. Follow your healthcare provider’s instructions on how to take/when to stop this medicine.
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sleepiness or falling asleep during the day is common and may be serious.. Some
people may get sleepy during the day or fall asleep
without warning while doing everyday activities such as talking, eating, or driving.
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dizziness is common and may be serious. ONAPGO can lower your blood pressure and
cause dizziness. Dizziness can happen when treatment is started
or when the dose is increased. Do not get up too fast from sitting or lying down, especially if you have been sitting or lying down for a long time.
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falls. Changes that can happen with PD, and
effects of some PD medicines, including ONAPGO, as well as trimethobenzamide, can increase the risk of falling.
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infusion site reaction is common and may be serious. Reactions and infections including infusion site nodules, redness, bruising, swelling, rash, and itching may happen
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hallucinations or psychotic-like behavior. ONAPGO can cause/ worsen psychotic-like behavior including hallucinations (seeing or hearing things that are not real), confusion, excessive suspicion, aggressive behavior, agitation, delusional beliefs (believing things that are not real), and disorganized thinking.
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sudden uncontrolled movements (dyskinesias) are common and may be serious.. Some
people with PD may get sudden, uncontrolled movements after treatment
with some PD medicines. ONAPGO can cause/make dyskinesias worse.
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low red blood cells (hemolytic anemia). Tell your
healthcare provider if you have:
become pale, fast heartbeat, feel more tired or weaker than usual,
skin or eyes look yellow, chest pain, shortness of breath or trouble
breathing, dark-colored urine, fever, dizziness, or confusion.
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strong (intense) urges. New or increased gambling urges, sexual urges, and
other intense urges, and other intense urges have been reported.
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heart problems. If you have shortness of breath, fast
heartbeat, or chest pain, call your healthcare
provider or get emergency help right away.
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serious heart rhythm changes (QT prolongation). Tell
your healthcare provider right away if you have a change in your
heartbeat (a fast or irregular heartbeat), or faint.
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allergic reaction. Tell your healthcare provider or get medical help right away if you get hives, itching, rash, swelling of the eyes and tongue, or trouble breathing.
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tissue changes (fibrotic complications). Some people
have had changes in the tissues of their pelvis, lungs, and heart valves
when taking medicines called non-ergot derived dopamine agonists like
ONAPGO.
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prolonged painful erections (priapism). May occur. If you have an erection that lasts more than 4 hours, call your healthcare provider or go to the nearest hospital emergency room right away.